Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of Iκ
, an endogenous blocker of NF-κ
B. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50
values are 80 and 17 μ
M respectively) and displays antitumor activity against breast cancer in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Gliotoxin and related epipolythiodioxopiperazines.
Waring and Beaver
In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats.
Fitzpatrick et al.
Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumour activity against breast cancer in vivo.
Vigushin et al.