Gliotoxin

Tocris Bioscience | Catalog # 2637

Inhibitor of 20S proteasome; immunosuppressant
Tocris Bioscience
Discontinued Product
2637 has been discontinued. View all NFkB/IkB Inhibitors products.

Key Product Details

Description

Inhibitor of 20S proteasome; immunosuppressant

Alternative Names

Aspergillin
View all NFkB/IkB Inhibitors »

Product Description

Gliotoxin is an immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of IκBα, an endogenous blocker of NF-κB. Inhibits leukotriene B4 (LTB4) biosynthesis via inhibition of LTA4 hydrolase. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays antitumor activity against breast cancer in vivo.

Product Specifications for Gliotoxin

Molecular Weight

326.38

Formula

C13H14N2O4S2

Storage

Desiccate at -20°C

Chemical Name

(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione

CAS Number

67-99-2

PubChem ID

6223

InChI Key

FIVPIPIDMRVLAY-RBJBARPLSA-N

SMILES

O=C([C@@]2(SS4)N(C([C@@]43CO)=O)[C@@H]1[C@@H](O)C=CC=C1C2)N3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for Gliotoxin

Certificate of Analysis

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Product Specific Notices for Gliotoxin

For research use only

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