Catalog Number: 2637
Alternate Names: Aspergillin
Chemical Name: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
Biological Activity
Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of IκBα, an endogenous blocker of NF-κB. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays antitumor activity against breast cancer in vivo.
Technical Data
  • M.Wt:
    326.38
  • Formula:
    C13H14N2O4S2
  • Solubility:
    Soluble in DMSO and in ethanol
  • Storage:
    Desiccate at -20°C
  • CAS No:
    67-99-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Gliotoxin and related epipolythiodioxopiperazines.
    Waring and Beaver
    Gen.Pharmacol., 1996;27:1311
  2. In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats.
    Fitzpatrick et al.
    Dig.Dis.Sci., 2000;45:2327
  3. Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumour activity against breast cancer in vivo.
    Vigushin et al.
    Med.Oncol., 2004;21:21

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