Gliotoxin

Catalog # Availability Size / Price Qty
2637/1
Gliotoxin | CAS No. 67-99-2 | NFkB/IkB Inhibitors
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Description: Inhibitor of 20S proteasome; immunosuppressant
Alternative Names: Aspergillin

Chemical Name: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione

Product Details
Citations (1)
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Biological Activity

Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of IκBα, an endogenous blocker of NF-κB. Inhibits leukotriene B4 (LTB4) biosynthesis via inhibition of LTA4 hydrolase. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays antitumor activity against breast cancer in vivo.

Technical Data

M.Wt:
326.38
Formula:
C13H14N2O4S2
Solubility:
Soluble in DMSO and in ethanol
Storage:
Desiccate at -20°C
CAS No:
67-99-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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