Chemical Name: 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
Biological ActivityGPBAR-A is a gPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.
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Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion.
Parker et al.
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders.
Keitel et al.
Citation for GPBAR-A
The citations listed below are publications that use Tocris products. Selected citations for GPBAR-A include:
1 Citation: Showing 1 - 1
Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
Authors: Kowal Et al.
Stem Cells Transl Med 2015;13:28
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