GPBAR-A

Key Product Details

Product Description

GPBAR-A is a gPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.

Product Specifications for GPBAR-A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GPBAR-A

The following data is based on the product molecular weight 484.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.32 mL	20.65 mL
5 mM	0.41 mL	2.06 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Keitel The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009 PMID: 19582812
• Parker Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br.J.Pharmacol. 2012 PMID: 21718300

Product Documents for GPBAR-A