GR 125487 sulfamate
Chemical Name: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate
Biological ActivityGR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Role of 5-HT4 receptors in the mouse passive avoidance test.
Galeotti et al.
Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding.
Schiavi et al.
Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisp. in Suncus murinus.
Horikoshi et al.
Citations for GR 125487 sulfamate
The citations listed below are publications that use Tocris products. Selected citations for GR 125487 sulfamate include:
2 Citations: Showing 1 - 2
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
Authors: Orr Et al.
J Neurosci 2015;18:423
Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation.
Authors: Warner-Schmidt Et al.
Dis Model Mech 2009;29:1937
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