GR 125487 sulfamate

Key Product Details

Product Description

GR 125487 sulfamate is a potent and selective 5-HT₄ receptor antagonist (K_i = 0.19 nM for porcine 5-HT₄). Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for GR 125487 sulfamate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GR 125487 sulfamate

The following data is based on the product molecular weight 524.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.06 mL	95.31 mL	190.63 mL
0.5 mM	3.81 mL	19.06 mL	38.13 mL
1 mM	1.91 mL	9.53 mL	19.06 mL
5 mM	0.38 mL	1.91 mL	3.81 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Horikoshi Possible involvement of 5-HT₄ receptors, in addition to 5-HT₃ receptors, in the emesis induced by high-dose cisp. in Suncus murinus. Jpn.J.Pharmacol. 2001 PMID: 11243577
• Schiavi Identification of serotonin 5-HT₄ recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 1994 PMID: 7984293
• Galeotti Role of 5-HT₄ receptors in the mouse passive avoidance test. J.Pharmacol.Exp.Ther. 1998 PMID: 9732367

Product Documents for GR 125487 sulfamate