GR 125487 sulfamate

Catalog # Availability Size / Price Qty
GR 125487 sulfamate | CAS No. 859502-43-5 | 5-HT4 Receptor Antagonists
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Description: Potent and selective 5-HT4 antagonist; active in vivo

Chemical Name: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate

Purity: ≥97%

Product Details
Citations (2)
Supplemental Products

Biological Activity

GR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.

Technical Data

Soluble to 10 mM in water with gentle warming
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

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Citations for GR 125487 sulfamate

The citations listed below are publications that use Tocris products. Selected citations for GR 125487 sulfamate include:

2 Citations: Showing 1 - 2

  1. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
    Authors: Orr Et al.
    J Neurosci  2015;18:423
  2. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation.
    Authors: Warner-Schmidt Et al.
    Dis Model Mech  2009;29:1937


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