Home / Prostanoid Receptor Antagonists / GW 627368

GW 627368

Catalog #: 4668
1 Citation Datasheet / COA / SDS
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4668/50
GW 627368 | CAS No. 439288-66-1 | Prostanoid Receptor Antagonists
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Description: Selective EP4 receptor competitive antagonist

Chemical Name: 4-(4-,9-Diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)benzeneacetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GW 627368 is a selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platelet aggregation.

Technical Data

M.Wt:
544.62
Formula:
C30H28N2O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
439288-66-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

Product Datasheets

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Citation for GW 627368

The citations listed below are publications that use Tocris products. Selected citations for GW 627368 include:

1 Citation: Showing 1 - 1

  1. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets.
    Authors: Ed&#233;n Et al.
    Diabetologia  2015;58:2563

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