GW 788388

  ( 4 citations )    
Product Datasheet
Catalog Number:3264
Chemical Name:4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent inhibitor of transforming growth factor-β type I receptor (ALK5) (IC50 values are 18 and 93 nM for ALK5 binding and for TGF-β cellular assay respectively). Inhibits esophageal squamous cell carcinoma (ESCC)-induced neoangiogenesis. Orally active.
Technical Data
  • M.Wt:
    425.48
  • Formula:
    C25H23N5O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    452342-67-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 788388 include:

4 Citations: Showing 1 - 4
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  1. Transforming Growth Factor Beta 1 Modulates the Functional Expression of the Neurokinin-1 Receptor in Human Keratocytes.
    Authors: Roux Et al.
    Curr Eye Res  2016;41:1035
  2. Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy.
    Authors: Castillero Et al.
    Biochem Biophys Res Commun  2015;457:106
  3. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One  2015;10:e0123641
  4. RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression.
    Authors: Jajosky Et al.
    Stem Cells Transl Med  2014;3:836

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