Chemical Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Biological ActivityDopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis.
Beresford and Ward
Inhibition of N-MthD.-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors.
Lynch and Gallagher
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
Subtype-selective inhibition of N-MthD.-aspartate receptors by halope.
IIyin et al.
A SARS-CoV-2 protein-protein interaction map reveals drug targets and drug repurposing.
Gordon et al.
Citations for Haloperidol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Haloperidol hydrochloride include:
9 Citations: Showing 1 - 9
Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
Authors: Joshi and Panicker
Theσ-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands.
Authors: Mishra Et al.
Brain Res 2015;466:263
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
J Biomol Screen 2015;40:766
Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
Authors: Canfrán-Duque Et al.
Biochem J 2015;10:e0141829
Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression.
Authors: Kim Et al.
Biochem Biophys Res Commun 2012;426:177
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein.
Authors: Watson Et al.
Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk.
Authors: Oliver and Davies
Hum Mol Genet 2009;18:4576
Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
Authors: Balu Et al.
Brain Res 2008;1211:37
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I used haloperidol hydrochloride to block D2 dopamine receptors, which increases phosphorylation of the Akt protein (see the western blot image).