Catalog Number: 0931
Chemical Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Biological Activity
Dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 25 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis.
    Beresford and Ward
    Drugs, 1987;33:31
  3. Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.
    IIyin et al.
    Mol.Pharmacol., 1996;50:1541
  4. Inhibition of N-methyl-D-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors.
    Lynch and Gallagher
    J.Pharmacol.Exp.Ther., 1996;279:154
  5. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
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