Haloperidol hydrochloride

Catalog # Availability Size / Price Qty
Haloperidol hydrochloride | CAS No. 1511-16-6 | Non-selective Dopamine Receptor Antagonists
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Description: Dopamine antagonist; displays some D2 selectivity

Chemical Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products

Biological Activity

Haloperidol hydrochloride is a dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data

Soluble to 10 mM in ethanol with gentle warming and to 25 mM in DMSO with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Haloperidol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Haloperidol hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Haloperidol hydrochloride include:

9 Citations: Showing 1 - 9

  1. Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
    Authors: Joshi and Panicker
    Eneuro  2019;5
  2. Theσ-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands.
    Authors: Mishra Et al.
    Brain Res  2015;466:263
  3. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    J Biomol Screen  2015;40:766
  4. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Biochem J  2015;10:e0141829
  5. Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression.
    Authors: Kim Et al.
    Biochem Biophys Res Commun  2012;426:177
  6. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci  2012;15:1245
  7. The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein.
    Authors: Watson Et al.
    Neuropsychopharmacology  2012;1436:111
  8. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk.
    Authors: Oliver and Davies
    Hum Mol Genet  2009;18:4576
  9. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
    Authors: Balu Et al.
    Brain Res  2008;1211:37


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