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(±)-HIP-B

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(±)-HIP-B | CAS No. 227619-65-0 | Glutamate (EAAT) Transporter Inhibitors
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Description: Potent, non-competitive EAAT inhibitor

Chemical Name: (±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid

Purity: ≥98%

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Biological Activity

Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 35 and 45 μM respectively).

Technical Data

M.Wt:
172.14
Formula:
C6H8N2O4
Solubility:
Soluble to 20 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
227619-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
    Conti et al.
    J.Med.Chem., 1999;42:4099
  2. Synthesis of new bicyclic analogues of glutamic acid.
    Conti et al.
    Tetrahedron, 1999;55:5623
  3. Dissociation of [3H]glutamate uptake from glutamate-induced [3H]D-Aspartate release by 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrro
    Funicello et al.
    Mol.Pharmacol., 2004;66:522

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