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(±)-HIP-B

   
Product Datasheet
Catalog Number:2218
Chemical Name:(±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid
Product Details
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Biological Activity
Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 35 and 45 μM respectively).
Technical Data
  • M.Wt:
    172.14
  • Formula:
    C6H8N2O4
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    227619-65-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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