Biological ActivityHOE 140 is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = D-Tic, X-9 = Oic)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.
Hock et al.
Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species.
Feletou et al.
The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.
Bawolak et al.
Citations for HOE 140
The citations listed below are publications that use Tocris products. Selected citations for HOE 140 include:
5 Citations: Showing 1 - 5
Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2.
Authors: Zhou Et al.
Int J Oncol 2019;55:131
Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus.
Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
Authors: Raffai Et al.
Journal of Vascular Research 2016;53:105
Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
Authors: Kawaguchi Et al.
Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.
Authors: Xu Et al.
Am J Respir Cell Mol Biol 2014;51:370
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