Catalog Number: 3014
Alternate Names: Icatibant
Biological Activity
Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
Technical Data
  • M.Wt:
    1304.52
  • Formula:
    C59H89N19O13S
  • Sequence:
    RRPXGXSXXR

    (Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    130308-48-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.
    Hock et al.
    Br.J.Pharmacol., 1991;102:769
  2. Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species.
    Feletou et al.
    Br.J.Pharmacol., 1994;112:683
  3. The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.
    Bawolak et al.
    Eur.J.Pharmacol., 2006;551:108
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HOE 140 include:

2 Citations: Showing 1 - 2
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  1. Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
    Authors: Raffai Et al.
    Journal of Vascular Research 2016;53:105
  2. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
    Authors: Kawaguchi Et al.
    Oncogene 2015;9:229
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