Catalog Number: 3014
Alternate Names: Icatibant
Biological Activity
Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.
    Hock et al.
    Br.J.Pharmacol., 1991;102:769
  2. Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species.
    Feletou et al.
    Br.J.Pharmacol., 1994;112:683
  3. The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.
    Bawolak et al.
    Eur.J.Pharmacol., 2006;551:108

The citations listed below are publications that use Tocris products. Selected citations for HOE 140 include:

Showing Results 1 - 1 of 1

  1. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
    Authors: Kawaguchi Et al.
Tocris Peptides
Description Application Cat# Citations Images  

MEN 11270

View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information