Human Semaphorin 3A Alexa Fluor® 700-conjugated Antibody Summary
Lys26-Val771 (Arg555Ala, Arg552Ala)
Accession # Q14563
Preparation and Storage
Background: Semaphorin 3A
The Semaphorins constitute a large family of secreted, GPI-anchored and transmembrane cell signaling molecules. Depending on their domain organization and species origin, these proteins can be classified into eight groups. To date, at least 19 vertebrate Semaphorins belonging to five groups (class 3 through 7) have been identified. All Semaphorins contain a conserved, 500 amino acid (aa) Sema domain at the amino terminus. Semaphorins are best known for their roles in axon guidance during neuronal development. Semaphorins are also expressed in non-neuronal tissues and are involved in angiogenesis, hematopoiesis, organogenesis, and the regulation of immune functions (1, 2).
Class 3 Semaphorins (Sema3) are secreted proteins containing a Sema domain, an immunoglobulin c2-like domain and a basic domain near the carboxyl tail. Sema3A (also referred to as SemaIII, SemD and Collapsin) cDNA predicts a 771 aa precursor protein with a putative 25 aa signal peptide (1‑3). Bioactive Sema3A is a disulfide-linked dimer (4). The bioactivity is increased after proteolytic processing by a furin-like endoprotease near the carboxy-terminus (1). The functional receptor complex for Sema3 is composed of two distinct transmembrane proteins: Neuropilin-1 (Npn-1) and Plexin-A. Npn-1 binds directly to Sema3A with high-affinity and confers specificity. Plexin-A interacts with Npn-1 to increase the affinity of the complex for Sema3A and serves as the signaling subunit in the receptor complex (1, 2, 5).
- Nakamura, F. et al. (2000) J Neurobiol. 44:219.
- Goshima, Y. et al. (2002) J. Clin. Invest. 109:993.
- Kolodkin, A.L. et al. (1993) Cell 75:1389.
- Koppel, A.M. et al. (1998) J. Biol. Chem. 273:15708.
- Yu, T.W. et al. (2001) Nature Neurosci. Supplement 4:1169.
- Luo Y. et al. (1993) Cell 75:217.
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human Semaphorin 3A Alexa Fluor® 700-conjugated Antibody
There are currently no reviews for this product. Be the first to review Human Semaphorin 3A Alexa Fluor® 700-conjugated Antibody and earn rewards!
Have you used Human Semaphorin 3A Alexa Fluor® 700-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image