Catalog Number: 3913
Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid
Biological Activity
RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence.
Background References
  1. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
    Umemiya et al.
    J.Med.Chem., 1997;40:4222
  2. Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.
    Ohashi et al.
    J.Vet.Med.Sci., 2002;64:169
  3. Clinically potential subclasses of retinoid synergists revealed by gene expression profiling.
    Ishida et al.
    Mol.Cancer Ther., 2003;2:49
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