AM 80

Key Product Details

Product Description

AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED₅₀ = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.

Product Specifications for AM 80

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AM 80

The following data is based on the product molecular weight 351.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.69 mL	28.45 mL	56.91 mL
2.5 mM	1.14 mL	5.69 mL	11.38 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
25 mM	0.11 mL	0.57 mL	1.14 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Kasamoto Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart. Stem Cell Reports 2023 PMID: 37451261
• Jimi RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 2007 PMID: 17611697
• Takenaga The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 2009 PMID: 19182380
• Kagechika Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 1988 PMID: 3184125

Product Documents for AM 80