Retinoic acid receptor α
) agonist that induces differentiation (ED50
= 0.79 nM) and apoptosis of HL-60 cells in vitro
. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μ
M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo
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All Tocris products are intended for laboratory research use only.
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Kagechika et al.
RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells.
Jimi et al.
The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats.
Takenaga et al.
The citations listed below are publications that use Tocris products. Selected citations for AM 80 include:
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