Catalog Number: 3507
Alternate Names: Tamibarotene
Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Biological Activity
Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
    Kagechika et al.
    J.Med.Chem., 1988;31:2182
  2. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells.
    Jimi et al.
    Int.J.Oncol., 2007;31:397
  3. The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats.
    Takenaga et al.
    Biol.Pharm.Bull., 2009;32:225

The citations listed below are publications that use Tocris products. Selected citations for AM 80 include:

Showing Results 1 - 1 of 1

  1. Exogenous�Modulation�of�Retinoic�Acid�Signaling�Affects�Adult�RGC�Survival�in the�Frog�Visual�System�afterOptic�Nerve�Injury
    Authors: Duprey-Díaz Et al.
    PLoS One
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