AM 80

Catalog # Availability Size / Price Qty
3507/10
3507/50
AM 80 | CAS No. 94497-51-5 | Retinoic Acid Receptor Agonists
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Description: RARα agonist; anticancer agent
Alternative Names: Tamibarotene

Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.

Technical Data

M.Wt:
351.44
Formula:
C22H25NO3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
94497-51-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for AM 80

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