Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Biological ActivityAM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Kagechika et al.
RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells.
Jimi et al.
The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats.
Takenaga et al.
Citation for AM 80
The citations listed below are publications that use Tocris products. Selected citations for AM 80 include:
1 Citation: Showing 1 - 1
Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury
Authors: Duprey-Díaz Et al.
PLoS One 2016;11:e0162626
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