IB-MECA

Key Product Details

Product Description

IB-MECA is a potent and selective A₃ adenosine receptor agonist (K_i values are 1.1, 54 and 56 nM for A₃, A₁ and A_2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.

Licensing Information

Sold with the permission of the NIH, US Patent 08/091,109

Product Specifications for IB-MECA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IB-MECA

The following data is based on the product molecular weight 510.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.84 mL	39.19 mL	78.39 mL
1.25 mM	1.57 mL	7.84 mL	15.68 mL
2.5 mM	0.78 mL	3.92 mL	7.84 mL
12.5 mM	0.16 mL	0.78 mL	1.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 112 publications citing the usage of this product.

• Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
• Park N⁶-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3β. J.Pharmacol.Exp.Ther. 2006 PMID: 16611852
• Gallo-Rodriguez Structure-activity relationships of N⁶-benzyladenosine-5'-uronamides as A₃-selective adenosine agonists. J.Med.Chem. 1994 PMID: 8126704

Product Documents for IB-MECA