Potent and selective A3
adenosine receptor agonist (Ki
values are 1.1, 54 and 56 nM for A3
receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.
Soluble to 25 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of the NIH, US Patent 08/091,109
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.
Gallo-Rodriguez et al.
Adenosine receptors and their ligands.
Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3β.
Park et al.
The citations listed below are publications that use Tocris products. Selected citations for IB-MECA include:
Showing Results 1 - 10 of 11