IB-MECA

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IB-MECA | CAS No. 152918-18-8 | Adenosine A3 Receptor Agonists
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Description: A3 selective agonist

Chemical Name: 1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide

Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

Potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.

Technical Data

Formula:
C18H19IN6O4
Solubility:
Soluble to 25 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
152918-18-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the NIH, US Patent 08/091,109

Product Datasheets

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Citations for IB-MECA

The citations listed below are publications that use Tocris products. Selected citations for IB-MECA include:

12 Citations: Showing 1 - 10

  1. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling  2016;
  2. Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
    Authors: Ford Et al.
    J.Neurosci.  2015;35:6057
  3. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
    Authors: Eusemann Et al.
    PLoS One  2015;10:e0134934
  4. A3 adenosine receptor agonist prevents the development of PacT.-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
    Authors: Janes Et al.
    Pain  2014;155:2560
  5. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
    Authors: Kozma Et al.
    Biochem Pharmacol  2013;85:1171
  6. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    Authors: He Et al.
    FASEB J  2013;27:3446
  7. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
    Authors: Park Et al.
    Kidney Int  2012;82:878
  8. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
    Authors: Stoddart Et al.
    Chem Biol  2012;19:1105
  9. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
    Authors: Keene Et al.
    Biochem Pharmacol  2010;80:188
  10. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
    Authors: Kornerup Et al.
    Br J Pharmacol  2005;144:1011

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