Catalog Number: 2845
Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Biological Activity
Phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.
Technical Data
  • M.Wt:
    222.24
  • Formula:
    C10H14N4O2
  • Solubility:
    Soluble to 75 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    28822-58-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
    Freitag et al.
    Eur.J.Pharmacol., 1998;354:67
  2. cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
    Lepski et al.
    Front.Cell Neurosci., 2013;7:155
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IBMX include:

7 Citations: Showing 1 - 7
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  1. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab 2015;308:E130
  2. The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
    Authors: Ghosh Et al.
    Eneuro 2015;2015:308461
  3. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    PLoS One 2015;2
  4. Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
    Authors: Cooke Et al.
    Biomed Res Int 2015;172:593
  5. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Am J Physiol Lung Cell Mol Physiol 2015;10:e0132884
  6. Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
    Authors: Cuppoletti Et al.
    Cell Biochem Biophys 2013;66:53
  7. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Br J Pharmacol 2012;35:507

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