Phosphodiesterase inhibitor (IC50
values are 13, 18, 19, 32 and 50 μ
M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α
-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50
= 1.3 μ
M). Facilitates differentiation of neural progenitor cells in vitro
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Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
Freitag et al.
cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
Lepski et al.
Front.Cell Neurosci., 2013;7:155
The citations listed below are publications that use Tocris products. Selected citations for IBMX include:
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