Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Biological ActivityPhosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
Lepski et al.
Front.Cell Neurosci., 2013;7:155
Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
Freitag et al.
Citations for IBMX
The citations listed below are publications that use Tocris products. Selected citations for IBMX include:
18 Citations: Showing 1 - 10
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.
Authors: An Et al.
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
Authors: Jewell Et al.
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Authors: Patra Et al.
Nat Cell Biol 2018;20:811
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Authors: Burdyga Et al.
Proc Natl Acad Sci U S A. 2018;115(28):E6497
Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM.
Authors: Demeautis Et al.
Sci Rep 2017;7:41026
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium.
Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Authors: Havekes Et al.
J Neurosci 2016;36:8936
Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions.
Authors: Foster Et al.
Sci Rep 2015;5:10839
Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Authors: Elliott Et al.
Am J Physiol Endocrinol Metab 2015;308:E130
MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
Authors: Lundegaard Et al.
Chem Biol 2015;22:1335
The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
Authors: Ghosh Et al.
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
PLoS One 2015;2
Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
Authors: Cooke Et al.
Biomed Res Int 2015;172:593
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Authors: Merino Et al.
Am J Physiol Lung Cell Mol Physiol 2015;10:e0132884
Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
Authors: Cuppoletti Et al.
Am J Physiol Cell Physiol 2014;307:C479
Methadone but not mor. inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Authors: Cuppoletti Et al.
Cell Biochem Biophys 2013;66:53
DArgic modulation of ganglion-cell photoreceptors in rat.
Authors: Hook Et al.
Br J Pharmacol 2012;35:507
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Exogenous application of IBMX on brain slices