IBMX

  ( 10 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2845
Chemical Name:3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Product Details
Citations (10)
Reviews
Biological Activity
Phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.
Technical Data
  • M.Wt:
    222.24
  • Formula:
    C10H14N4O2
  • Solubility:
    Soluble to 75 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    28822-58-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IBMX include:

10 Citations: Showing 1 - 10
Filter your results:

  1. Crystal structure of the GLP-1 receptor bound to a peptide agonist.
    Authors: Jazayeri
    Nature  2017;546:254
  2. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab  2015;308:E130
  3. MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
    Authors: Lundegaard Et al.
    Chem Biol  2015;22:1335
  4. The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
    Authors: Ghosh Et al.
    Eneuro  2015;2015:308461
  5. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    PLoS One  2015;2
  6. Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
    Authors: Cooke Et al.
    Biomed Res Int  2015;172:593
  7. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;10:e0132884
  8. Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
    Authors: Cuppoletti Et al.
    Am J Physiol Cell Physiol  2014;307:C479
  9. Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
    Authors: Cuppoletti Et al.
    Cell Biochem Biophys  2013;66:53
  10. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Br J Pharmacol  2012;35:507

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Average Rating: 5 (Based on 1 review)

Have you used IBMX?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Read what people are saying who have used IBMX.

We have 1 review tested in 1 species: Mouse.

Filter by Ratings
Excellent
(1)
All Ratings
Filter by Applications
All Applications
Filter by Species
Mouse
(1)
All Species

Images Ratings Applications Species Reviewed By Date Details
  Excellent
  Mouse Anonymous 01/04/2018
Show

Summary

Species Mouse

Other Experimental Details

Other Experimental Details Effect is observed within minutes.

Please scroll the above reviews for more
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee