Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Biological ActivitySelective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy.
Amato et al.
ACS Med.Chem.Lett., 2011;2:481
The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility.
Provence et al.
Citations for ICA 069673
The citations listed below are publications that use Tocris products. Selected citations for ICA 069673 include:
2 Citations: Showing 1 - 2
Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
Authors: Vicente-Baz Et al.
Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.
Authors: Brueggemann Et al.
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ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.