ICA 069673

Tocris Bioscience | Catalog # 4305

KV7.2/KV7.3 channel opener
Tocris Bioscience

Key Product Details

Description

KV7.2/KV7.3 channel opener
View all Voltage-gated Potassium Channel Activators »

Product Description

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Product Specifications for ICA 069673

Molecular Weight

269.63

Formula

C11H6ClF2N3O

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

CAS Number

582323-16-8

PubChem ID

10149311

InChI Key

IIBSHMFXVWTQSJ-UHFFFAOYSA-N

SMILES

ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.96 100
Ethanol 6.74 25

Preparing Stock Solutions for ICA 069673

The following data is based on the product molecular weight 269.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.54 mL 37.09 mL
5 mM 0.74 mL 3.71 mL 7.42 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for ICA 069673

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ICA 069673

For research use only

Customer Reviews for ICA 069673 (1)

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  • ICA 069673 was used to study Kv channel opening on brain tissues of rodents
    Name: Eleanor Baxter
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 10/23/2018
    ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.
    ICA 069673 4305

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