Home / Voltage-gated Potassium Channel Activators / ICA 069673

ICA 069673

4305 2 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4305/25
4305/5
ICA 069673 | CAS No. 582323-16-8 | Voltage-gated Potassium Channel Activators
1 Image
Description: KV7.2/KV7.3 channel opener

Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Technical Data

M.Wt:
269.63
Formula:
C11H6ClF2N3O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
582323-16-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for ICA 069673

The citations listed below are publications that use Tocris products. Selected citations for ICA 069673 include:

2 Citations: Showing 1 - 2

  1. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
    Authors: Vicente-Baz Et al.
    Neuropharmacology  2016;109:131
  2. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.
    Authors: Brueggemann Et al.
    Mol.Pharmacol.  2014;2014:330

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ICA 069673

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used ICA 069673?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


ICA 069673 was used to study Kv channel opening on brain tissues of rodents
By Eleanor Baxter on 10/23/2018
Application: Species: Rat

ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.