Home / Voltage-gated Potassium Channel Activators / ICA 069673

ICA 069673

4305 2 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4305/25
4305/5
Voltage-gated Potassium Channel Activators Small Molecule
1 Image
Description: KV7.2/KV7.3 channel opener

Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Technical Data

M.Wt:
269.63
Formula:
C11H6ClF2N3O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
582323-16-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ICA 069673

The citations listed below are publications that use Tocris products. Selected citations for ICA 069673 include:

2 Citations: Showing 1 - 2

  1. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
    Authors: Vicente-Baz Et al.
    Neuropharmacology  2016;109:131
  2. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.
    Authors: Brueggemann Et al.
    Mol.Pharmacol.  2014;2014:330

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ICA 069673 was used to study Kv channel opening on brain tissues of rodents
By Eleanor Baxter on 10/23/2018
Species: Rat

ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.

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