7.3 (KCNQ2/3) channel opener (EC50
= 0.69 μ
M). Exhibits 20-fold selectivity for KV
7.3 over KV
7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility.
Provence et al.
N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy.
Amato et al.
ACS Med.Chem.Lett., 2011;2:481
The citations listed below are publications that use Tocris products. Selected citations for ICA 069673 include:
Showing Results 1 - 1 of 1