ICA 069673

Catalog # Availability Size / Price Qty
4305/25
4305/5
ICA 069673 | CAS No. 582323-16-8 | Voltage-gated Potassium Channel Activators
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Description: KV7.2/KV7.3 channel opener

Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Technical Data

M.Wt:
269.63
Formula:
C11H6ClF2N3O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
582323-16-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ICA 069673

The citations listed below are publications that use Tocris products. Selected citations for ICA 069673 include:

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ICA 069673 was used to study Kv channel opening on brain tissues of rodents
By Eleanor Baxter on 10/23/2018
Species: Rat

ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.


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