Microtubule destabilizer that blocks tubulin polymerization (IC50
= 0.3 μ
M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro
values ranging from 0.036 - 0.285 μ
M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo
. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
Soluble to 25 mM in DMSO
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity.
Bacher et al.
Cancer Res., 2001;61:392
Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in malignant glioma cells through Bcl-2 phosphorylation and Bax translocation.
Kanzawa et al.
Indibulin, a novel microtubule inhibitor, discriminates between mature and nonneuronal tubulin.
Wienecke and Bacher
Cancer Res., 2009;69:171