Indibulin

Catalog # Availability Size / Price Qty
3728/10
3728/50
Indibulin | CAS No. 204205-90-3 | Microtubule Binding Compounds
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Description: Microtubule destabilizer
Alternative Names: D 24851

Chemical Name: 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide

Purity: ≥98%

Product Details
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Biological Activity

Microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

Technical Data

M.Wt:
389.83
Formula:
C22H16ClN3O2
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
204205-90-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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