Catalog Number: 0779
Chemical Name: N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Biological Activity
Selective H3 antagonist with high affinity (KD = 0.3 nM). Also available as part of the Histamine H3 Receptor Tocriset™.
Technical Data
  • M.Wt:
    576.13
  • Formula:
    C15H19IN4S.2HBr
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    145196-87-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of SCI, Amsterdam
Background References
  1. The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes.
    Jansen et al.
    Eur.J.Pharmacol., 1992;217:203
  2. Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain.
    Jansen et al.
    Br.J.Pharmacol., 1994;113:355
  3. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Iodophenpropit dihydrobromide include:

2 Citations: Showing 1 - 2
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  1. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
    Authors: Otvos Et al.
    BMC Neurosci 2015;7:2336
  2. Serotonergic neuron regulation informed by in vivo single-cell transcriptomics.
    Authors: Spaethling Et al.
    Toxins (Basel) 2014;28:771

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