Iodophenpropit dihydrobromide

Catalog # Availability Size / Price Qty
0779/10
0779/50

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Iodophenpropit dihydrobromide | CAS No. 145196-87-8 | Histamine H3 Receptor Antagonists
1 Image
Description: Potent, selective H3 antagonist

Chemical Name: N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Iodophenpropit dihydrobromide is a selective H3 antagonist with high affinity (KD = 0.3 nM).

Technical Data

M.Wt:
576.13
Formula:
C15H19IN4S.2HBr
Solubility:
Soluble to 25 mM in water
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
145196-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of SCI, Amsterdam

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes.
    Jansen et al.
    Eur.J.Pharmacol., 1992;217:203
  3. Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain.
    Jansen et al.
    Br.J.Pharmacol., 1994;113:355
  4. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  5. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9

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Citations for Iodophenpropit dihydrobromide

The citations listed below are publications that use Tocris products. Selected citations for Iodophenpropit dihydrobromide include:

2 Citations: Showing 1 - 2

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