Iodophenpropit dihydrobromide

Catalog # Availability Size / Price Qty
0779/10
0779/50
Cat.No. 0779 - Iodophenpropit dihydrobromide | C15H19IN4S.2HBr | CAS No. 145196-87-8
1 Image
Description: Potent, selective H3 antagonist

Chemical Name: N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Selective H3 antagonist with high affinity (KD = 0.3 nM). Also available as part of the Histamine H3 Receptor Tocriset™.

Technical Data

M.Wt:
576.13
Formula:
C15H19IN4S.2HBr
Solubility:
Soluble to 25 mM in water
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
145196-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold with the permission of SCI, Amsterdam

Background References

  1. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II.
    Bruno et al.
    Synthesis, 2010;24:4193
  2. The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes.
    Jansen et al.
    Eur.J.Pharmacol., 1992;217:203
  3. Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain.
    Jansen et al.
    Br.J.Pharmacol., 1994;113:355
  4. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  5. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  6. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  7. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  8. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  9. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  10. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  11. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  12. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  13. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  14. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  15. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  16. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  17. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  18. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  19. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  20. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  21. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  22. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  23. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  24. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  25. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  26. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  27. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  28. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  29. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  30. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  31. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  32. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  33. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  34. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  35. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  36. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  37. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  38. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  39. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  40. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  41. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  42. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  43. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  44. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  45. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  46. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  47. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  48. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  49. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  50. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  51. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  52. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  53. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  54. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  55. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  56. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  57. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  58. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  59. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  60. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  61. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9
  62. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  63. Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9

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