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IT 901

Catalog #: 5846 Datasheet / COA / SDS

Discontinued Product

5846 has been discontinued.
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IT 901 | CAS No. 1584121-99-2 | NFkB/IkB Inhibitors
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Description: NF-κB c-Rel subunit inhibitor

Chemical Name: 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

Purity: ≥98%

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Biological Activity

IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. Reduces severity of graft-versus-host disease following hematopoietic stem cell transplant (HSCT) and inhibits growth of human B-cell lymphoma xenografts in mice. Inhibits the oxidative stress response in lymphoma cells.

Technical Data

M.Wt:
342.37
Formula:
C17H14N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1584121-99-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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