Inhibitor of Hedgehog signaling (IC50
= 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.
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All Tocris products are intended for laboratory research use only.
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
Williams et al.
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.
ten Berge et al.
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Cooper et al.