Jervine

Tocris Bioscience | Catalog # 4717

Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
Tocris Bioscience
Discontinued Product
4717 has been discontinued. View all Hedgehog Signaling Inhibitors products.

Key Product Details

Description

Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
View all Hedgehog Signaling Inhibitors »

Product Description

Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.

Product Specifications for Jervine

Molecular Weight

425.60

Formula

C27H39NO3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one

CAS Number

469-59-0

PubChem ID

10098

InChI Key

CLEXYFLHGFJONT-DNMILWOZSA-N

SMILES

O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@](CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])C3=[C@@]4C)([H])[C@@]([H])1C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.51 20
Ethanol 21.28 50

Preparing Stock Solutions for Jervine

The following data is based on the product molecular weight 425.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.70 mL 23.50 mL 46.99 mL
2.5 mM 0.94 mL 4.70 mL 9.40 mL
5 mM 0.47 mL 2.35 mL 4.70 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Jervine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Jervine

For research use only

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