Jervine

Catalog # Availability Size / Price Qty
4717/10
Cat.No. 4717 - Jervine | C27H39NO3 | CAS No. 469-59-0
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Description: Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo

Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one

Purity: ≥98%

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Biological Activity

Inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.

Technical Data

M.Wt:
425.6
Formula:
C27H39NO3
Solubility:
Soluble to 50 mM in ethanol and to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
469-59-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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