High affinity, selective NOP receptor antagonist (Ki
= 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ
- and δ
-opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo
. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801.
Yamada et al.
4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.
Shinkai et al.
Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation.
Tamai et al.
The citations listed below are publications that use Tocris products. Selected citations for JTC 801 include:
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