Chemical Name: N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride
Biological ActivityJTC 801 is a high affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.
Shinkai et al.
Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801.
Yamada et al.
Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation.
Tamai et al.
Citations for JTC 801
The citations listed below are publications that use Tocris products. Selected citations for JTC 801 include:
3 Citations: Showing 1 - 3
Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder.
Authors: Zhang Et al.
PLoS One 2015;172:571
Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats.
Authors: Delaney Et al.
J Neuroendocrinol 2012;24:1527
Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.
Authors: Mahmoud Et al.
Mol Pharmacol 2010;77:804
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