Catalog Number: 2287
Alternate Names: Staurosporinone
Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Biological Activity
Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).
Technical Data
  • M.Wt:
    311.34
  • Formula:
    C20H13N3O
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    85753-43-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Kinase inhibitors: not just for kinases anymore.
    McGovern and Shoichet
    J.Med.Chem., 2003;46:1478
  2. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.
    Fabre et al.
    Bioorg.Med.Chem., 1993;1:193
  3. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
    Zimmermann et al.
    Antiviral Res., 2000;48:49
Citations:

The citations listed below are publications that use Tocris products. Selected citations for K-252c include:

1 Citations: Showing 1 - 1

  1. An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes.
    Authors: Goldman Et al.
    Chem Biol 2012;19:855

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