Inhibitor of protein kinase C (IC50
= 2.45 μ
M) that displays ~ 10-fold selectivity over protein kinase A (IC50
= 25.7 μ
M). Also inhibits β
-lactamase, malate dehydrogenase and chymotrypsin (IC50
values are 8, 8 and 10 μ
M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50
values range from 0.13 - 0.32 μ
M). Shows no activity against herpes simplex virus (HSV).
Soluble to 25 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kinase inhibitors: not just for kinases anymore.
McGovern and Shoichet
Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.
Fabre et al.
Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
Zimmermann et al.
Antiviral Res., 2000;48:49
The citations listed below are publications that use Tocris products. Selected citations for K-252c include:
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