Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Biological ActivityInhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.
Fabre et al.
Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
Zimmermann et al.
Antiviral Res., 2000;48:49
Kinase inhibitors: not just for kinases anymore.
McGovern and Shoichet
Citation for K-252c
The citations listed below are publications that use Tocris products. Selected citations for K-252c include:
1 Citation: Showing 1 - 1
An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes.
Authors: Goldman Et al.
Chem Biol 2012;19:855
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