Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Biological ActivityK-252c is an inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.
Fabre et al.
Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
Zimmermann et al.
Antiviral Res., 2000;48:49
Kinase inhibitors: not just for kinases anymore.
McGovern and Shoichet
Citation for K-252c
The citations listed below are publications that use Tocris products. Selected citations for K-252c include:
1 Citation: Showing 1 - 1
An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes.
Authors: Goldman Et al.
Chem Biol 2012;19:855
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