K-252c

Catalog # Availability Size / Price Qty
2287/1
K-252c | CAS No. 85753-43-1 | Protein Kinase C Inhibitors
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Description: Protein kinase C inhibitor
Alternative Names: Staurosporinone

Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).

Technical Data

M.Wt:
311.34
Formula:
C20H13N3O
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
85753-43-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for K-252c

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