KB-R7943 mesylate

  ( 31 citations )    
Product Datasheet
Catalog Number:1244
Chemical Name:2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate
Product Details
Citations (31)
Reviews
Biological Activity
Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 μM). Also inhibits the mitochondrial Ca2+ uniporter (MCU; IC50 = 5.5 μM). Does not affect Na+-dependent transport systems or ionotropic glutamate receptors.
Technical Data
  • M.Wt:
    427.49
  • Formula:
    C16H17N3O3S.CH3SO3H
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    182004-65-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for KB-R7943 mesylate include:

31 Citations: Showing 1 - 10
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  1. KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment.
    Authors: Hernandez-Ojeda Et al.
    J Biomed Sci  2017;24:27
  2. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell Rep  2017;21(4):1009
  3. Transient receptor potential canonical (TRPC)/Orai1-dependent store-operated Ca2+ channels: New targets of aldosterone in cardiomyocytes.
    Authors: Sabourin Et al.
    J.Biol.Chem.  2016;291:13394
  4. Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine.
    Authors: Virsolvy Et al.
    Am J Physiol Renal Physiol  2015;5:17969
  5. A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease.
    Authors: Vinberg Et al.
    Hum Mol Genet  2015;24:5915
  6. An inhibitor of Na(+)/Ca(2+) exchange blocks activation of insect olfactory receptors.
    Authors: Bobkov Et al.
    Biochem Biophys Res Commun  2014;450:1104
  7. The effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra.
    Authors: Drumm Et al.
    Physiol Rep  2014;2:e00203
  8. Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity.
    Authors: Chouhan Et al.
    J Neurosci  2012;32:1233
  9. Pro-death and pro-survival properties of ouabain in U937 lymphoma derived cells.
    Authors: Cuozzo Et al.
    J Exp Clin Cancer Res  2012;31:95
  10. The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption.
    Authors: Pan Et al.
    Biochem Biophys Res Commun  2012;302:F943
  11. Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.
    Authors: Pandit Et al.
    Am J Physiol Renal Physiol  2012;302:F1325
  12. Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers.
    Authors: Roberts Et al.
    Br J Pharmacol  2012;165:922
  13. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.
    Authors: Cheng Et al.
    Br J Pharmacol  2012;165:2260
  14. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
    Authors: Yamamura Et al.
    Circ Res  2012;111:469
  15. Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPase.
    Authors: Cheng Et al.
    Cell Calcium  2011;49:56
  16. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
    Authors: Xu Et al.
    Proc Natl Acad Sci U S A  2011;406:200
  17. PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes.
    Authors: Poteser Et al.
    Am J Physiol Regul Integr Comp Physiol  2011;108:10556
  18. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
    Authors: Kim Et al.
    Sci Rep  2010;19:783
  19. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
    Authors: Barrientos Et al.
    Mol Pharmacol  2009;76:560
  20. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex.
    Authors: Chao Et al.
    Cell Mol Life Sci  2009;66:1105
  21. Mitochondrial regulation of sarcoplasmic reticulum Ca2+ content in vascular smooth muscle cells.
    Authors: Poburko Et al.
    Circ Res  2009;104:104
  22. The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction.
    Authors: Pezier Et al.
    J Neurophysiol  2009;101:1151
  23. Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.
    Authors: Kansui Et al.
    Cell Calcium  2008;44:135
  24. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
    Authors: Baltan Et al.
    Stem Cells Dev  2008;28:1479
  25. Mechanisms of the lysophosphatidic acid-induced increase in [Ca(2+)](i) in skeletal muscle cells.
    Authors: Xu Et al.
    J Cell Mol Med  2008;12:942
  26. Activation of subfornical organ neurons in rats through pre- and postsynaptic α-adrenoceptors.
    Authors: Honda Et al.
    Nat Protoc  2006;290:R1646
  27. Ionic mechanisms of cardiac cell swelling induced by blocking Na+/K+ pump as revealed by experiments and simulation.
    Authors: Takeuchi Et al.
    J Gen Physiol  2006;128:495
  28. Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia.
    Authors: Baczkó Et al.
    FASEB J  2005;19:980
  29. Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum.
    Authors: Kohlmeier Et al.
    J Neurophysiol  2004;92:221
  30. Effects of Na+/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes.
    Authors: Spencer and Sham
    Am J Physiol Heart Circ Physiol  2003;285:H2552
  31. Motility initiation in herring sperm is regulated by reverse sodium-calcium exchange.
    Authors: Vines Et al.
    Proc Natl Acad Sci U S A  2002;99:2026
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