Potent, selective inhibitor of the reverse mode of the Na+
= 0.7 μ
M). Also inhibits the mitochondrial Ca2+
uniporter (MCU; IC50
= 5.5 μ
M). Does not affect Na+
-dependent transport systems or ionotropic glutamate receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
Hoyt et al.
The plasma membrane +/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.
Santo-Domingo et al.
The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxia/hypoglycemic injury.
Schr?der et al.
Effect of +/Ca2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs.
Watano et al.
The citations listed below are publications that use Tocris products. Selected citations for KB-R7943 mesylate include:
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