Chemical Name: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Biological ActivityMBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation.
Zhu et al.
Cancer Cell, 2018;33:1004
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