KCC 07

Key Product Details

Product Description

KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.

Product Specifications for KCC 07

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KCC 07

The following data is based on the product molecular weight 269.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.57 mL	37.13 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhu BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 2018 PMID: 29894688

Product Documents for KCC 07