Chemical Name: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Biological ActivityMBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation.
Zhu et al.
Cancer Cell, 2018;33:1004
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