( 6 citations )    
Product Datasheet
Catalog Number:0681
Chemical Name:[1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Product Details
Citations (6)
Supplemental Products
Biological Activity
A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Product Datasheets

The citations listed below are publications that use Tocris products. Selected citations for L-690,330 include:

6 Citations: Showing 1 - 6
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  1. LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1.
    Authors: Harding Et al.
    Infect Immun  2013;81:4261
  2. Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques.
    Authors: Meyer Et al.
    Br J Pharmacol  2011;162:1410
  3. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
    Authors: Sarkar Et al.
    J Cell Biol  2008;17:170
  4. Regulation of autophagy by the inositol trisphosphate receptor.
    Authors: Criollo Et al.
    Cell Death Differ  2007;14:1029
  5. Lithium induces autophagy by inhibiting inositol monophosphatase.
    Authors: Sarkar Et al.
    Infect Immun  2005;170:1101
  6. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity.
    Authors: Westfall Et al.
    J Cell Biol  2003;162:889


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