Catalog Number: 0681
Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Biological Activity
A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.
    Atack et al.
    J.Neurochem., 1993;60:652
  2. Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers.
    Atack et al.
    J.Pharmacol.Exp.Ther., 1994;270:70
  3. Chemical modulators of autophagy as biological probes and potential therapeutics.
    Fleming et al.
    Nat.Chem.Biol., 2011;7:9
  4. Lithium induces autophagy by inhibiting inositol monophosphatase.
    Sarkar et al.
    J.Cell.Biol., 2005;170:1101
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