Catalog Number: 0681
Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Biological Activity
A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
Technical Data
  • M.Wt:
    298.13
  • Formula:
    C8H12O8P2
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    142523-38-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.
    Atack et al.
    J.Neurochem., 1993;60:652
  2. Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers.
    Atack et al.
    J.Pharmacol.Exp.Ther., 1994;270:70
  3. Chemical modulators of autophagy as biological probes and potential therapeutics.
    Fleming et al.
    Nat.Chem.Biol., 2011;7:9
  4. Lithium induces autophagy by inhibiting inositol monophosphatase.
    Sarkar et al.
    J.Cell.Biol., 2005;170:1101
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-690,330 include:

6 Citations: Showing 1 - 6
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  1. LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1.
    Authors: Harding Et al.
    Infect Immun 2013;81:4261
  2. Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques.
    Authors: Meyer Et al.
    Br J Pharmacol 2011;162:1410
  3. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
    Authors: Sarkar Et al.
    J Cell Biol 2008;17:170
  4. Regulation of autophagy by the inositol trisphosphate receptor.
    Authors: Criollo Et al.
    Cell Death Differ 2007;14:1029
  5. Lithium induces autophagy by inhibiting inositol monophosphatase.
    Authors: Sarkar Et al.
    Infect Immun 2005;170:1101
  6. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity.
    Authors: Westfall Et al.
    J Cell Biol 2003;162:889
Tocris Small Molecules
Description Application Cat# Citations Images  

L-690,488

0682 1  
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