Catalog Number: 0907
Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Biological Activity
An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
Technical Data
  • M.Wt:
    363.8
  • Formula:
    C21H14ClNO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    142326-59-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324 in rodents.
    Bristow et al.
    J.Pharmacol.Exp.Ther., 1996;277:578
  2. Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex.
    Bristow et al.
    J.Pharmacol.Exp.Ther., 1996;279:492
  3. 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.
    Kulagowski et al.
    J.Med.Chem., 1994;37:1402
  4. Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex.
    Obrenovitch and Zilkha
    Br.J.Pharmacol., 1996;117:931
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-701,324 include:

1 Citations: Showing 1 - 1

  1. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking.
    Authors: Bäckström and Hyytiä
    Neuropsychopharmacology 2006;31:778

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