L-755,507

  ( 4 citations )    
Product Datasheet
Catalog Number:2197
Chemical Name:4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).
Technical Data
  • M.Wt:
    584.73
  • Formula:
    C30H40N4O6S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    159182-43-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-755,507 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.
    Authors: Pinder Et al.
    Nucleic Acids Res  2015;43:9379
  2. Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?.
    Authors: Afeli Et al.
    Am J Physiol Renal Physiol  2012;302:F251
  3. Promiscuous aggregate-based inhibitors promote enzyme unfolding.
    Authors: Coan Et al.
    J Med Chem  2009;52:2067
  4. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.
    Authors: Coan and Shoichet
    J Am Chem Soc  2008;130:9606

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used L-755,507?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee