Chemical Name: 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Biological ActivityL-755,507 is a potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecules enhance CRISPR genome editing in pluripotent stem cells.
Yu et al.
Cell Stem Cell, 2015;16:142
Discovery of L-755,507: a subnanomolar human β3 adrenergic receptor agonist.
Parmee et al.
A selective human β3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys.
Fisher et al.
Citations for L-755,507
The citations listed below are publications that use Tocris products. Selected citations for L-755,507 include:
6 Citations: Showing 1 - 6
Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells.
Authors: Riesenberg and Maricic
Nat Commun 2018;9:2164
Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells.
Authors: Kornete Et al.
J Immunol 2018;200:2489
Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.
Authors: Pinder Et al.
Nucleic Acids Res 2015;43:9379
Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?.
Authors: Afeli Et al.
Am J Physiol Renal Physiol 2012;302:F251
Promiscuous aggregate-based inhibitors promote enzyme unfolding.
Authors: Coan Et al.
J Med Chem 2009;52:2067
Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.
Authors: Coan and Shoichet
J Am Chem Soc 2008;130:9606
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