Catalog Number: 2197
Chemical Name: 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Biological Activity
Potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).
Technical Data
  • M.Wt:
    584.73
  • Formula:
    C30H40N4O6S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    159182-43-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of L-755,507: a subnanomolar human β3 adrenergic receptor agonist.
    Parmee et al.
    Bioorg.Med.Chem.Lett., 1998;8:1107
  2. A selective human β3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys.
    Fisher et al.
    J.Clin.Invest., 1998;101:2387
  3. Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells.
    Yu et al.
    Cell Stem Cell, 2015;16:142
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-755,507 include:

1 Citations: Showing 1 - 1

  1. Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.
    Authors: Pinder Et al.
    Nucleic Acids Res 2015;43:9379

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