Chemical Name: N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
Biological ActivityL-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of subtype selective somatostatin receptor agonists.
Rohrer and Schaeffer
Somatostatin inhibits Ins and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Strowski et al.
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer et al.
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