Potent and selective somatostatin sst5
receptor agonist. Ki
values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5
receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50
= 3.1 nM) and insulin release from mouse pancreatic islets (EC50
= 0.3 nM) in vitro
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All Tocris products are intended for laboratory research use only.
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer et al.
Identification and characterization of subtype selective somatostatin receptor agonists.
Rohrer and Schaeffer
Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Strowski et al.