Catalog Number: 1980
Chemical Name: N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
Biological Activity
Potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.
Technical Data
  • M.Wt:
    536.67
  • Formula:
    C33H36N4O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    217480-27-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
    Rohrer et al.
    Science, 1998;282:737
  2. Identification and characterization of subtype selective somatostatin receptor agonists.
    Rohrer and Schaeffer
    J.Physiol.Paris, 2000;94:211
  3. Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
    Strowski et al.
    Endocrinology, 2000;141:111

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