L-Azidonorleucine hydrochloride

Catalog # Availability Size / Price Qty
L-Azidonorleucine hydrochloride | CAS No. 1454334-76-9 | Unnatural Amino Acids
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Description: Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins

Chemical Name: (S)-2-Amino-6-azidohexanoic acid hydrochloride

Product Details

Biological Activity

L-Azidonorleucine hydrochloride is an unnatural amino acid; surrogate methionine. Can be incorporated into proteins by a mutant methionyl tRNA synthetase to enable cell-type specific analysis of protein synthesis. For use with bio-orthogonal non-canonical amino-acid tagging (BONCAT) or fluorescent non-canonical amino acid tagging (FUNCAT). Labeling does not affect the normal localization of the labeled proteins.

Technical Data

Soluble to 100 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cell-type-specific metabolic labeling of nascent proteomes in vivo.
    Alvarez-Castelao et al.
    Nat.Biotechnol., 2017;35:1196
  2. Engineered aminoacyl-tRNA synthetase for cell-selective analysis of mammalian protein synthesis.
    Mahdavi et al.
    J.Am.Chem.Soc., 2016;138:4278

Product Datasheets

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