Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]acetic acid hydrazide
Biological ActivityTransglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Structure-activity relationship study of novel tissue transglutaminase inhibitors.
Duval et al.
Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor.
Case and Stein
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
Prime et al.
Citation for LDN 27219
The citations listed below are publications that use Tocris products. Selected citations for LDN 27219 include:
1 Citation: Showing 1 - 1
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
Authors: Yeo Et al.
Mediators Inflamm 2016;5
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