LDN 27219
Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]acetic acid hydrazide
Purity: ≥99%
Biological Activity
LDN 27219 is a transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor.
Case and Stein
Biochemistry, 2007;46:1106 -
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
Prime et al.
J.Med.Chem., 2012;55:1021 -
Structure-activity relationship study of novel tissue transglutaminase inhibitors.
Duval et al.
Bioorg.Med.Chem.Lett., 2005;15:1885
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Citation for LDN 27219
The citations listed below are publications that use Tocris products. Selected citations for LDN 27219 include:
1 Citation: Showing 1 - 1
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Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
Authors: Yeo Et al.
Mediators Inflamm 2016;5
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