Catalog Number: 4602
Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]acetic acid hydrazide
Biological Activity
Transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.
Technical Data
  • M.Wt:
    408.5
  • Formula:
    C20H16N4O2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    312946-37-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
    Prime et al.
    J.Med.Chem., 2012;55:1021
  2. Structure-activity relationship study of novel tissue transglutaminase inhibitors.
    Duval et al.
    Bioorg.Med.Chem.Lett., 2005;15:1885
  3. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor.
    Case and Stein
    Biochemistry, 2007;46:1106
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LDN 27219 include:

1 Citations: Showing 1 - 1

  1. Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
    Authors: Yeo Et al.
    Mediators Inflamm 2016;5

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