LDN 27219

Key Product Details

Product Description

LDN 27219 is a transglutaminase 2 (TG2) inhibitor (IC₅₀ = 0.25 μM). Binds at GTPase site; reversible.

Product Specifications for LDN 27219

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LDN 27219

The following data is based on the product molecular weight 408.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Prime Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J.Med.Chem. 2012 PMID: 22224594
• Duval Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15780627
• Case and Stein Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 2007 PMID: 17240993

Product Documents for LDN 27219