Catalog Number: 1378
Alternate Names: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Biological Activity
Active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
Technical Data
  • M.Wt:
    286.33
  • Formula:
    C16H18N2O3
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    94535-50-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.
    Buckle et al.
    J.Med.Chem., 1991;34:919
  2. Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227).
    Noack et al.
    Br.J.Pharmacol., 1992;107:945
  3. The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways.
    Taylor et al.
    J.Pharmacol.Exp.Ther., 1992;261:429
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Levcromakalim include:

1 Citations: Showing 1 - 1

  1. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Lab Chip 2015;10:e0121634

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