LG 101506

Key Product Details

Product Description

LG 101506 is a selective RXR modulator (K_i values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (K_i values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.

Product Specifications for LG 101506

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LG 101506

The following data is based on the product molecular weight 420.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Leibowitz Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 2006 PMID: 16269450
• Pinaire Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 2007 PMID: 17497022
• Michellys Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 2003 PMID: 12801232

Product Documents for LG 101506