Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Biological ActivityLG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
Michellys et al.
Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.
Leibowitz et al.
Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome.
Pinaire et al.
PPAR Res., 2007;:94156
Citation for LG 101506
The citations listed below are publications that use Tocris products. Selected citations for LG 101506 include:
1 Citation: Showing 1 - 1
Retinoic Acid regulates hematopoietic development from human pluripotent stem cells.
Authors: Ronn Et al.
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