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LG 101506

3508 1 Citation Datasheet / COA / SDS
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3508/10
3508/50
LG 101506 | CAS No. 331248-11-4 | Retinoid X Receptor Modulators
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Description: Selective RXR modulator
Alternative Names: LG 1506

Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.

Technical Data

M.Wt:
420.53
Formula:
C25H34F2O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
331248-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for LG 101506

The citations listed below are publications that use Tocris products. Selected citations for LG 101506 include:

1 Citation: Showing 1 - 1

  1. Retinoic Acid regulates hematopoietic development from human pluripotent stem cells.
    Authors: Ronn Et al.
    Development  2015;4:269

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