Selective RXR modulator (Ki
values are 3, 9 and 11 for RXRα
respectively). Displays poor binding affinity for RAR isoforms (Ki
values are 2746, 3516 and >10,000 nM for RARα
respectively). Binding to RXR results in selective activation of RXR:PPARγ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
Michellys et al.
Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.
Leibowitz et al.
Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome.
Pinaire et al.
PPAR Res., 2007;:94156
The citations listed below are publications that use Tocris products. Selected citations for LG 101506 include:
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