Catalog Number: 3508
Alternate Names: LG 1506
Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Biological Activity
Selective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.
Technical Data
  • M.Wt:
    420.53
  • Formula:
    C25H34F2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    331248-11-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
    Michellys et al.
    J.Med.Chem., 2003;46:2683
  2. Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.
    Leibowitz et al.
    Endocrinology, 2006;147:1044
  3. Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome.
    Pinaire et al.
    PPAR Res., 2007;:94156
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LG 101506 include:

1 Citations: Showing 1 - 1

  1. Retinoic Acid regulates hematopoietic development from human pluripotent stem cells.
    Authors: Ronn Et al.
    Development 2015;4:269

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