Chemical Name: 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride
Biological ActivityCytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
Van Wauwe et al.
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.
Njar et al.
Effects of liarozole fumarate (R85246) in combination with tamox. on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model.
Goss et al.
BMC Cancer, 2007;7:26
Citations for Liarozole dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Liarozole dihydrochloride include:
3 Citations: Showing 1 - 3
Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.
Authors: Bunt Et al.
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
Authors: Bhattacharya Et al.
Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
Authors: Thomas and Henry
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