Liarozole dihydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2705
Alternate Names:R-75251
Chemical Name:5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride
Product Details
Citations (3)
Reviews
Biological Activity
Cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.
Technical Data
  • M.Wt:
    381.69
  • Formula:
    C17H13ClN4.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Liarozole dihydrochloride include:

3 Citations: Showing 1 - 3
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  1. Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.
    Authors: Bunt Et al.
    Islets  2016;8:83
  2. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
    Authors: Bhattacharya Et al.
    Immunity  2016;45:1
  3. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
    Authors: Thomas and Henry
    Neuropsychopharmacology  2014;386:291

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