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(-)-Lobeline hydrochloride

Catalog #: 1077 Datasheet / COA / SDS

Discontinued Product

1077 has been discontinued.
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(-)-Lobeline hydrochloride | CAS No. 134-63-4 | Additional Nicotinic Receptor Agonists
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Description: Nicotinic partial agonist

Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride

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Biological Activity

(-)-Lobeline hydrochloride is a high affinity, partial agonist with a Ki value of 4.4 nM in rat brain.

Technical Data

M.Wt:
373.92
Formula:
C22H27NO2.HCl
Solubility:
Soluble to 50 mM in ethanol and to 10 mM in water
Storage:
Store at RT
CAS No:
134-63-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice.
    Farook et al.
    Physiol.Behav., 2009;97:503
  3. Pharmacology of lobeline, a nicotinic receptor ligand.
    Damaj et al.
    J.Pharmacol.Exp.Ther., 1997;282:410

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