Catalog Number: 5606
Chemical Name: 2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one
Biological Activity
High affinity protein disulfide isomerase (PDI) modulator (Kd = 62 nM). Forces PDI to adopt an oxidized conformation and suppresses its activity. Neuroprotective.
Technical Data
  • M.Wt:
    317.41
  • Formula:
    C16H19N3O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    877963-94-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.
    Kaplan et al.
    Proc.Natl.Acad.Sci.U.S.A., 2015;112:E2245

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