Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α
, IL-6 and inducible nitric oxide production and blocks NF-κ
B and AP-1 activation. Also inhibits TNF-α
-induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo
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All Tocris products are intended for laboratory research use only.
A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells.
Ju et al.
Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage.
Chen et al.
Life Sci., 2007;81:1602
Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells.
Kim et al.