Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Biological ActivityLuteolin is an anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (Mpro or 3CLpro).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells.
Ju et al.
Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage.
Chen et al.
Life Sci., 2007;81:1602
Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression.
Yan et al.
Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking.
Yu et al.
Citations for Luteolin
The citations listed below are publications that use Tocris products. Selected citations for Luteolin include:
2 Citations: Showing 1 - 2
Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells.
Authors: Cook Et al.
Breast Cancer (Dove Med Press) 2017;9:9
Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts.
Authors: Cook Et al.
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