Luteolin

Catalog # Availability Size / Price Qty
2874/10
2874/50
Luteolin | CAS No. 491-70-3 | Additional Antioxidant Compounds
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Description: Anti-inflammatory, antioxidant and free radical scavenger
Alternative Names: 3',4',5,7-Tetrahydroxyflavone

Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo.

Technical Data

M.Wt:
286.24
Formula:
C15H10O6
Solubility:
Soluble to 5 mM in 1eq. NaOH and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
491-70-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells.
    Kim et al.
    J.Pharm.Exp.Ther., 2011;338:1013
  2. A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells.
    Ju et al.
    Mol.Pharmacol., 2007;71:1381
  3. Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage.
    Chen et al.
    Life Sci., 2007;81:1602
  4. Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells.
    Kim et al.
    Ann.N.Y.Acad.Sci., 2007;1090:597

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Citations for Luteolin

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2 Citations: Showing 1 - 2

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