Luteolin

Key Product Details

Product Description

Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (M^pro or 3CL^pro).

Product Specifications for Luteolin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Luteolin

The following data is based on the product molecular weight 286.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.99 mL	34.94 mL	69.87 mL
2.5 mM	1.40 mL	6.99 mL	13.97 mL
5 mM	0.70 mL	3.49 mL	6.99 mL
25 mM	0.14 mL	0.70 mL	1.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

• Yu Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking. Int.J.Antimicrob.Agents 2020 PMID: 32389723
• Yan Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression. J.Nat.Med. 2019 PMID: 30758716
• Kim Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 2011 PMID: 21705614
• Kim Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 2007 PMID: 17410645
• Chen Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 2007 PMID: 17977562
• Ju A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 2007 PMID: 17296806

Product Documents for Luteolin