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LY 2389575 hydrochloride

Catalog #: 4969 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4969/10
4969/50
LY 2389575 hydrochloride | CAS No. 885104-09-6 | Group II mGluR Modulators
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Description: Selective negative allosteric modulator of mGlu3 receptors

Chemical Name: (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride

Purity: ≥98%

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Biological Activity

LY 2389575 hydrochloride is a selective negative allosteric modulator of mGlu3 (IC50 = 190 nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.

Technical Data

M.Wt:
438.58
Formula:
C15H15BrCl2N4.HCl
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
885104-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human mGluR2 (NP_000830) VersaClone cDNA

RDC0989

Human mGluR3 (NP_000831) VersaClone cDNA

RDC1012

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