Selective negative allosteric modulator of mGlu3
= 190 nM). Exhibits > 65-fold selectivity for mGlu3
over other mGlu receptors. Abolishes the neuroprotective action of LY 379268
against amyloid β
toxicity in mixed cortical neuronal and astrocyte cell cultures.
Soluble to 20 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGl
Caraci et al.