Chemical Name:(3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride
Biological Activity Selective negative allosteric modulator of mGlu3 (IC50 = 190 nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.
Soluble to 20 mM in DMSO
Desiccate at RT
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