Catalog Number: 1524
Chemical Name: (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
Biological Activity
Selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons.
    Ann.N.Y.Acad.Sci., 1994;713:300
  2. Central nervous system characterization of the new cholecystokininB antagonist LY288513.
    Helton et al.
    Pharmacol.Biochem.Behav., 1996;53:493
  3. Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain dopamine neurons.
    Rasmussen et al.
    J.Pharmacol.Exp.Ther., 1992;264:480

The citations listed below are publications that use Tocris products. Selected citations for LY 288513 include:

1 Citations: Showing 1 - 1

  1. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.
    Authors: Wen Et al.
    Front Endocrinol (Lausanne) 2012;13:63

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