Chemical Name: 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
Biological ActivityDynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1.
Mallat et al.
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