Orally active 5-HT2A
receptor antagonist; displays selectivity for 5-HT2A
receptors over 5-HT2C
values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A
, human 5-HT2A
, rabbit 5-HT2C
and human 5-HT2C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors.
Aloyo and Harvey
Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT2 receptors.
Dudley et al.
Drug Dev.Res., 1988;13:29
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
The citations listed below are publications that use Tocris products. Selected citations for MDL 11,939 include:
Showing Results 1 - 6 of 6