Chemical Name: α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Biological ActivityMDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors.
Aloyo and Harvey
Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT2 receptors.
Dudley et al.
Drug Dev.Res., 1988;13:29
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
Citations for MDL 11,939
The citations listed below are publications that use Tocris products. Selected citations for MDL 11,939 include:
8 Citations: Showing 1 - 8
Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
Authors: Corcoran Et al.
J Neurosci 2014;34:51
Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
Authors: Goda Et al.
Psychopharmacology (Berl) 2013;228:271
Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz.
Authors: Williams Et al.
LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor.
Authors: Halberstadt and Geyer
Psychopharmacology (Berl) 2010;208:179
Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.
Authors: Ptak Et al.
Biomol Ther (Seoul) 2009;29:3720
Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development.
Authors: Hodges Et al.
J Neurosci 2009;29:10341
5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
Authors: Yu and Yamaguchi
J Neurophysiol 2009;102:752
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