MDL 11,939

  ( 6 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0870
Chemical Name:α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).
Technical Data
  • M.Wt:
    295.42
  • Formula:
    C20H25NO
  • Solubility:
    Soluble to 50 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    107703-78-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MDL 11,939 include:

6 Citations: Showing 1 - 6
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  1. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    J Neurosci  2014;34:51
  2. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl)  2013;228:271
  3. Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.
    Authors: Williams Et al.
    Neuropsychopharmacology  2012;37:2285
  4. LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor.
    Authors: Halberstadt and Geyer
    Psychopharmacology (Berl)  2010;208:179
  5. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.
    Authors: Ptak Et al.
    Biomol Ther (Seoul)  2009;29:3720
  6. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
    Authors: Yu and Yamaguchi
    J Neurophysiol  2009;102:752

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