MDL 11,939

Catalog # Availability Size / Price Qty
0870/10
0870/50
MDL 11,939 | CAS No. 107703-78-6 | 5-HT2A Receptor Antagonists
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Description: 5-HT2A antagonist

Chemical Name: α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol

Purity: ≥99%

Product Details
Citations (8)
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Reviews

Biological Activity

MDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).

Technical Data

M.Wt:
295.42
Formula:
C20H25NO
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
107703-78-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

  1. Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors.
    Aloyo and Harvey
    Eur.J.Pharmacol., 2000;406:163
  2. Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT2 receptors.
    Dudley et al.
    Drug Dev.Res., 1988;13:29
  3. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
    Jensen et al.
    J.Med.Chem., 2013;56:1211

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Citations for MDL 11,939

The citations listed below are publications that use Tocris products. Selected citations for MDL 11,939 include:

8 Citations: Showing 1 - 8

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