Human 5-HT2A (NP_000612) VersaClone cDNA Summary
5-HT2A encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in 5-HT2A are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of 5-HT2A show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene.
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