Q: I saw that you have the antibodies for the both receptors of melatonin but not listed with FACS application. I need more information about what is better for my assay.

A: At this time, none of our melatonin receptor antibodies have been tested and validated in Flow. Should you choose to purchase and test one of them, you would qualify for the Innovator's Rewards program. You should take a look at each individual antibody, the clonality, conjugates, immunogen region and all relevant data in order to decide which product would be most suitable for your needs.

Melatonin Receptor 1B Antibody Blocking Peptide

Novus Biologicals | Catalog # NLS932PEP

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Applications

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Product Specifications

Description

A Melatonin Receptor 1B antibody blocking peptide.

Application Notes

This peptide is useful as a blocking peptide for NLS932. For further blocking peptide related protocol, click here. To block the specific antibody activity in immunohistochemistry analysis, pre-incubate the antibody with a 10-100X molar excess of peptide for 60 minutes at room temperature. Optimization of the molar ratio of antigen to antibody may be required. Centrifugation of the pre-adsorbed solution prior to addition to the slide may decrease background due to non-specific binding of large antibody-antigen complexes.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation, and Storage

NLS932PEP

Formulation	PBS, pH 7.4
Preservative	No Preservative
Concentration	1.0 mg/ml
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: Melatonin Receptor 1B

Melatonin receptor type 1B (MTNR1B) is a member of the G-protein coupled receptor 1 family. This family is responsible for translating external chemical signals across the cell membrane. MTNR1B is one of two high affinity receptors for melatonin, a hormone secreted by the pineal gland. Pertussis toxin sensitive G proteins, that inhibit adenylate cyclase activity, control the MTNR1B receptor. MTNR1B is expressed in the retina, and to a lesser extent the brain and hippocampus. MTNR1B is thought to regulate reproduction, the circadian cycle, and neurological melatonin levels; as well as participate in light dependent function in the retina. Post translational modifications that may affect MTNR1B are disulfide bonds and glycosylation.

Alternate Names

FGQTL2, Mel 1b melatonin receptor, Mel1b receptor, MEL-1B-R, melatonin receptor 1B, melatonin receptor MEL1B, melatonin receptor type 1B, MT2

Gene Symbol

MTNR1B

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Product Specific Notices for Melatonin Receptor 1B Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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