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MK 217

   
Product Datasheet
Catalog Number:4014
Alternate Names:Alendronate sodium
Chemical Name:P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt
Product Details
Reviews
Biological Activity
Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.
Technical Data
  • M.Wt:
    271.08
  • Formula:
    C4H12NNaO7P2
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    129318-43-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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