ML 130

Catalog # Availability Size / Price Qty
4354/10
4354/50
ML 130 | CAS No. 799264-47-4 | NFkB/IkB Inhibitors
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Description: Inhibits NOD1-induced NF-κB activation

Chemical Name: 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine

Purity: ≥99%

Product Details
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Biological Activity

Potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.

Technical Data

M.Wt:
287.34
Formula:
C14H13N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
799264-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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