Potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50
values are 0.56 and >20 μ
M for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κ
B activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro
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Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.
Correa et al.
Identification of inhibitors of NOD1-induced nuclear factor-κB activation.
Khan et al.
ACS Med.Chem.Lett., 2011;2:780