Catalog Number: 4507
Chemical Name: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride
Biological Activity
Selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. Orally active.
Technical Data
  • M.Wt:
    405.79
  • Formula:
    C19H26Cl2N2O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1346233-68-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease.
    Xiang et al.
    ACS Chem.Neurosci., 2011;2:730
  2. Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys.
    Galvan et al.
    ACS Chem.Neurosci, 2016;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 218 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys.
    Authors: Galvan Et al.
    ACS Chem.Neurosci. 2016;7:1543

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