ML 218 hydrochloride

Key Product Details

Product Description

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC₅₀ values are 270 and 310 nM for Ca_v3.3 and Ca_v3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, K_ir6 (K_ATP) or K_V11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Product Specifications for ML 218 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 218 hydrochloride

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Galvan Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci 2016 PMID: 27596273
• Chakraborty ML218 HCl is more efficient than capsaicin in inhibiting bacterial antigen-induced Cal 27 oral cancer cell proliferation. Int.J.Mol.Sci. 2021 PMID: 34830441
• Xiang The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease. ACS Chem.Neurosci. 2011 PMID: 22368764

Product Documents for ML 218 hydrochloride