ML 239

Tocris Bioscience | Catalog # 4829

Breast cancer stem cell inhibitor
Tocris Bioscience
Discontinued Product
4829 has been discontinued. View all Stem Cell Signaling Compounds products.

Key Product Details

Description

Breast cancer stem cell inhibitor
View all Stem Cell Signaling Compounds »

Product Description

ML 239 is a breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.

Product Specifications for ML 239

Molecular Weight

346.60

Formula

C13H10Cl3N3O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide

CAS Number

1378872-36-6

PubChem ID

90488975

InChI Key

WOCCOXNODBCCGK-UHFFFAOYSA-N

SMILES

ClC1=C(OCC(N/N=C/C2=CC=CN2)=O)C(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.66 100
Ethanol 17.33 50

Preparing Stock Solutions for ML 239

The following data is based on the product molecular weight 346.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.85 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 239

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 239

For research use only

Customer Reviews for ML 239 (1)

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  • Action of ML 239 on CSC cell lines
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 10/12/2019
    Dissolved in DMSO
    ML 239 was tested to find whether it was toxic to two CSC-like lines.Gene expression studies showed altered gene expression in the NF kappa B pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML 239.
    ML 239 4829

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