Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
Biological ActivityML 239 is a breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.
Carmody et al.
Identification of a selective small molecule inhibitor of breast cancer stem cells.
Germain et al.
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ML 239 was tested to find whether it was toxic to two CSC-like lines.Gene expression studies showed altered gene expression in the NF kappa B pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML 239.