Catalog Number: 4829
Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
Biological Activity
Breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.
Technical Data
  • M.Wt:
    346.6
  • Formula:
    C13H10Cl3N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1378872-36-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a selective small molecule inhibitor of breast cancer stem cells.
    Germain et al.
    Bioorg.Med.Chem.Lett., 2012;22:3571
  2. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.
    Carmody et al.
    J.Biol.Chem., 2012;17:1204

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