ML 239
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Description: Breast cancer stem cell inhibitor
Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
Purity: ≥98%
Biological Activity
Breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.Technical Data
M.Wt:
346.6
Formula:
C13H10Cl3N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1378872-36-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.
Carmody et al.
J.Biol.Chem., 2012;17:1204 -
Identification of a selective small molecule inhibitor of breast cancer stem cells.
Germain et al.
Bioorg.Med.Chem.Lett., 2012;22:3571
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