ML 239

Catalog # Availability Size / Price Qty
4829/5
4829/25
ML 239 | CAS No. 1378872-36-6 | Stem Cell Signaling Compounds
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Description: Breast cancer stem cell inhibitor

Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

ML 239 is a breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.

Technical Data

M.Wt:
346.6
Formula:
C13H10Cl3N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1378872-36-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Action of ML 239 on CSC cell lines
By Anonymous on 10/12/2019
Application: Species: Human

ML 239 was tested to find whether it was toxic to two CSC-like lines.Gene expression studies showed altered gene expression in the NF kappa B pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML 239.


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