ML 3403
Chemical Name: [5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine
Purity: ≥98%
Biological Activity
ML 3403 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.
Laufer et al.
J.Med.Chem., 2003;46:3230 -
Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor.
Kammerer et al.
Drug Metab.Dispos., 2007;35:875
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