ML 9 hydrochloride
Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride
Biological ActivityML 9 hydrochloride is a selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
STIM and Orai: the long-awaited constituents of store-operated calcium entry.
Varnai et al.
Pharmacology of protein kinase inhibitors.
Hidaka and Koybashi
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
Seto et al.
Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors.
Hidaka and Hagiwara
Trends Pharmacol.Sci., 1987;8:162
Citations for ML 9 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:
4 Citations: Showing 1 - 4
Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
Authors: Dobson Et al.
J Pharmacol Exp Ther 2015;10:e0125974
Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro.
Authors: Kirschstein Et al.
Acta Pharmacol Sin 2014;35:74
An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
Authors: Siddoway Et al.
PLoS One 2013;33:11206
Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons.
Authors: Gruszczynska-Biegala Et al.
PLoS One 2011;6:e19285
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