Catalog Number: 0431
Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride
Biological Activity
Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).
Technical Data
  • M.Wt:
    361.29
  • Formula:
    C15H17ClN2O2S.HCl
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    105637-50-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. STIM and Orai: the long-awaited constituents of store-operated calcium entry.
    Varnai et al.
    TiPS, 2009;30:118
  2. Pharmacology of protein kinase inhibitors.
    Hidaka and Koybashi
    Annu.Rev.Pharmacol.Toxicol., 1992;32:377
  3. Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
    Seto et al.
    Eur.J.Pharmacol., 1991;195:267
  4. Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors.
    Hidaka and Hagiwara
    Trends Pharmacol.Sci., 1987;8:162
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Pharmacol Exp Ther 2015;10:e0125974
  2. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    PLoS One 2013;33:11206

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