ML 9 hydrochloride

Catalog # Availability Size / Price Qty
ML 9 hydrochloride | CAS No. 105637-50-1 | Myosin Light Chain Kinase Inhibitors
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Description: Myosin light chain kinase inhibitor

Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

Purity: ≥99%

Product Details
Citations (4)

Biological Activity

ML 9 hydrochloride is a selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

Technical Data

Soluble to 25 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. STIM and Orai: the long-awaited constituents of store-operated calcium entry.
    Varnai et al.
    TiPS, 2009;30:118
  2. Pharmacology of protein kinase inhibitors.
    Hidaka and Koybashi
    Annu.Rev.Pharmacol.Toxicol., 1992;32:377
  3. Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
    Seto et al.
    Eur.J.Pharmacol., 1991;195:267
  4. Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors.
    Hidaka and Hagiwara
    Trends Pharmacol.Sci., 1987;8:162

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Citations for ML 9 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

4 Citations: Showing 1 - 4


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