ML 9 hydrochloride

Key Product Details

Product Description

ML 9 hydrochloride is a selective MLCK inhibitor (K_i values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca²⁺ entry (SOCE).

Product Specifications for ML 9 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 9 hydrochloride

The following data is based on the product molecular weight 361.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.07 mL	55.36 mL	110.71 mL
1.25 mM	2.21 mL	11.07 mL	22.14 mL
2.5 mM	1.11 mL	5.54 mL	11.07 mL
12.5 mM	0.22 mL	1.11 mL	2.21 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Hidaka and Hagiwara Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci.
• Seto Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 1991 PMID: 1874276
• Varnai STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 2009 PMID: 19187978
• Hidaka and Koybashi Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 1992 PMID: 1605572

Product Documents for ML 9 hydrochloride