ML 9 hydrochloride

Catalog # Availability Size / Price Qty
0431/10
0431/50
Cat.No. 0431 - ML 9 hydrochloride | C15H17ClN2O2S.HCl | CAS No. 105637-50-1
1 Image
Description: Myosin light chain kinase inhibitor

Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

Purity: ≥99%

Product Details
Citations (4)
Reviews

Biological Activity

Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

Technical Data

M.Wt:
361.29
Formula:
C15H17ClN2O2S.HCl
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
105637-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. STIM and Orai: the long-awaited constituents of store-operated calcium entry.
    Varnai et al.
    TiPS, 2009;30:118
  2. Pharmacology of protein kinase inhibitors.
    Hidaka and Koybashi
    Annu.Rev.Pharmacol.Toxicol., 1992;32:377
  3. Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
    Seto et al.
    Eur.J.Pharmacol., 1991;195:267
  4. Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors.
    Hidaka and Hagiwara
    Trends Pharmacol.Sci., 1987;8:162

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for ML 9 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

4 Citations: Showing 1 - 4

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ML 9 hydrochloride

There are currently no reviews for this product. Be the first to review ML 9 hydrochloride and earn rewards!

Have you used ML 9 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.