Chemical Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid
Biological ActivityMM 11253 is a selective RARγ antagonist. Blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors.
Holmes et al.
Modulation of retinoic acid receptor function alters the growth inhibitor response of oral SCC cells to retinoids.
Le et al.
Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.
Dawson et al.
Cancer Res., 2001;61:4723
Citations for MM 11253
The citations listed below are publications that use Tocris products. Selected citations for MM 11253 include:
5 Citations: Showing 1 - 5
All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity.
Authors: Bi Et al.
Cell Biosci 2018;8:48
RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.
Authors: Uchibe Et al.
J Orthop Res 2017;35:1096
BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
Authors: Perri Et al.
Exp Cell Res 2014;327:183
Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.
Authors: Garnaas Et al.
Dev Biol 2012;372:178
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