Catalog Number: 3822
Chemical Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid
Biological Activity
Selective RARγ antagonist. Blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.
Technical Data
  • M.Wt:
    462.67
  • Formula:
    C28H30O2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    345952-44-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors.
    Holmes et al.
    J.Cell.Physiol., 2000;185:61
  2. Modulation of retinoic acid receptor function alters the growth inhibitor response of oral SCC cells to retinoids.
    Le et al.
    Oncogene, 2000;19:1457
  3. Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.
    Dawson et al.
    Cancer Res., 2001;61:4723
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MM 11253 include:

1 Citations: Showing 1 - 1

  1. Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.
    Authors: Garnaas Et al.
    Dev Biol 2012;372:178

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