MMK 1

Catalog # Availability Size / Price Qty
3537/1
MMK 1
1 Image
Description: Potent and selective FPR2 agonist
Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.

DMSO is not recommended as a solvent for this peptide.

Technical Data

Formula:
C75H123N19O18S
Sequence:
LESIFRSLLFRVM
Solubility:
Soluble to 1 mg/ml in 25% ethanol / water
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
271246-66-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1.
    Hu et al.
    J.Leukoc.Biol., 2001;70:155
  2. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.
    Klein et al.
    Nature Biotech., 1998;16:1334

Product Datasheets

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Citations for MMK 1

The citations listed below are publications that use Tocris products. Selected citations for MMK 1 include:

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FAQs

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Following protocol
By Christopher Durrant on 01/09/2020
Species: Human

looking at human formyl peptide receptor


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