Home / Formyl Peptide Receptor Agonists / MMK 1

MMK 1

Catalog #: 3537
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3537/1
MMK 1
1 Image
Description: Potent and selective FPR2 agonist

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity

MMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.

DMSO is not recommended as a solvent for this peptide.

Technical Data

M.Wt:
1610.97
Formula:
C75H123N19O18S
Sequence:
LESIFRSLLFRVM
Solubility:
Soluble to 0.50 mg/ml in 25% ethanol / water with sonication
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
271246-66-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1.
    Hu et al.
    J.Leukoc.Biol., 2001;70:155
  2. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.
    Klein et al.
    Nature Biotech., 1998;16:1334

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for MMK 1

The citations listed below are publications that use Tocris products. Selected citations for MMK 1 include:

2 Citations: Showing 1 - 2

  1. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
    Authors: Akoume Et al.
    Sci Rep  2019;9:10074
  2. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest  2013;123:443

FAQs

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VersaClone cDNA Plasmids

Human FPRL1/FPR2 (NP_001453) VersaClone cDNA

RDC0059

Mouse FPR2 (NP_032065) VersaClone cDNA

RDC0061

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