Biological ActivityMMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
DMSO is not recommended as a solvent for this peptide.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1.
Hu et al.
Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.
Klein et al.
Nature Biotech., 1998;16:1334
Citations for MMK 1
The citations listed below are publications that use Tocris products. Selected citations for MMK 1 include:
2 Citations: Showing 1 - 2
A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
Authors: Leoni Et al.
J Clin Invest 2013;123:443
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looking at human formyl peptide receptor