Catalog Number: 3537
Biological Activity
Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in 25% ethanol / water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1.
    Hu et al.
    J.Leukoc.Biol., 2001;70:155
  2. The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels.
    Karlsson et al.
    Cell Calcium, 2009;45:431
  3. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.
    Klein et al.
    Nature Biotech., 1998;16:1334

The citations listed below are publications that use Tocris products. Selected citations for MMK 1 include:

1 Citations: Showing 1 - 1

  1. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest 2013;123:443

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