MMPX
1 Image
Description: PDE1 inhibitor
Chemical Name: 8-Methoxymethyl-3-isobutyl-1-methylxanthine
Biological Activity
MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM).Technical Data
M.Wt:
266.3
Formula:
C12H18N4O3
Solubility:
Soluble to 100 mM in ethanol
Storage:
Store at RT
CAS No:
78033-08-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Glucagon-like peptide-2 directly regulates hypothalamic neurons expressing neuropeptides linked to appetite control in vivo and in vitro.
Dalvi PS, Belsham DD
Endocrinology, 2012;153(5):2385-97. -
Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro.
Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD
Endocrinology, 2012;153(5):2208-22. -
Methylxanthine inhibitors of phosphodiesterases.
Wells and Mille
Methods Enzymol., 1988;159:489
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