MRK 740

Tocris Bioscience | Catalog # 6803

Potent PRDM9 inhibitor
Tocris Bioscience
Discontinued Product
6803 has been discontinued. View all Lysine Methyltransferase Inhibitors products.

Key Product Details

Description

Potent PRDM9 inhibitor
View all Lysine Methyltransferase Inhibitors »

Product Description

MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.

Product Specifications for MRK 740

Molecular Weight

464.56

Formula

C25H32N6O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole

CAS Number

2387510-80-5

PubChem ID

137331596

InChI Key

NZYTZRHHBAJPKN-UHFFFAOYSA-N

SMILES

CC1=CC(N2CCC3(CC2)CN(CCN3C)C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 46.46 100
DMSO 46.46 100

Preparing Stock Solutions for MRK 740

The following data is based on the product molecular weight 464.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MRK 740

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MRK 740

For research use only

Related Research Areas

Epigenetics
Lysine Methyltransferases

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