MRK 740
Chemical Name: 3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole
Purity: ≥98%
Biological Activity
MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Additional Information
Background References
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Discovery of a chemical probe for PRDM9.
Allali-Hassani et al.
Nat.Commun., 2019;10:5759
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