MRK 740

Catalog # Availability Size / Price Qty
MRK 740 | CAS No. 2387510-80-5 | Lysine Methyltransferase Inhibitors
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Description: Potent PRDM9 inhibitor

Chemical Name: 3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole

Purity: ≥98%

Product Details

Biological Activity

MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.

Background References

  1. Discovery of a chemical probe for PRDM9.
    Allali-Hassani et al.
    Nat.Commun., 2019;10:5759

Product Datasheets

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