Home / Lysine Methyltransferase Inhibitors / MRK 740

MRK 740

6803 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6803/5
MRK 740 | Lysine Methyltransferase Inhibitors
1 Image
Description: Potent PRDM9 inhibitor

Chemical Name: 3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.

Technical Data

M.Wt:
464.56
Formula:
C25H32N6O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.

Background References

  1. Discovery of a chemical probe for PRDM9.
    Allali-Hassani et al.
    Nat.Commun., 2019;10:5759

Product Datasheets

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